<b>Serum free light chain-only multiple myeloma associated with multiple bone involvement and the t(11;14)(q13;q32)/</b><i><b>CCND1</b></i><b>-immunoglobulin heavy chain fusion gene: A report of three case</b><b>s </b>
نویسندگان
چکیده
منابع مشابه
Immunoglobulin heavy and light chain isotypes in multiple myeloma patients.
The frequency of expression of immunoglobulin (Ig) light and heavy chain isotypes was analyzed in myeloma proteins (M-proteins) from sera of 40 Indian patients with clinically established multiple myeloma. Patients samples were screened by a combination of electrophoresis, immunoelectrophoresis (IEP) and ELISA techniques in this study. We found that majority of the myeloma proteins (58%) were o...
متن کاملSerum Free Light-chain Assay for the Diagnosis, Management, and Prognosis of Multiple Myeloma
In recent decades, new serum biomarkers have been developed for routine laboratory practice, such as assaying serum free light chains and more recently, assaying immunoglobulin heavy and light chain isotypes (Hevylite). In this work, we highlight the interest of new biomarkers (Hevylite Test) in the management of monoclonal gammopathies because of the technical advantages it confers and the se...
متن کاملMonitoring IgA multiple myeloma: immunoglobulin heavy/light chain assays.
BACKGROUND The use of electrophoresis to monitor monoclonal immunoglobulins migrating in the β fraction may be difficult because of their comigration with transferrin and complement proteins. METHODS Immunoassays specific for IgGκ, IgGλ, IgAκ, IgAλ, IgMκ, and IgMλ heavy/light chain (HLC) were validated for use in the clinical laboratory. We assessed sample stability, inter- and intraassay var...
متن کاملImmunoglobulin light chain amyloidosis associated with multiple myeloma in a young patient: a case report.
The authors present an uncommon case of systemic amyloidosis associated with multiple myeloma in a 35-year old woman. Systemic amyloidosis commonly presents in association with clonal plasma cell proliferative disorders, and less frequently as secondary or of a hereditary origin. Amyloidosis is usually associated with multiple myeloma in older patients and frequently has an unfavourable prognosis.
متن کاملHeavy- and free light-chain myeloma associated with peripheral polyneuropathy.
Peripheral polyneuropathy, a rare complication of multiple myeloma, is generally associated with heavy-chain M-proteins and, in very rare instances, with free light-chain myeloma proteins. Here we describe a case of multiple myeloma and polyneuropathy with both monoclonal IgG and free lambda light chains in the blood. The patient also had free lambda light chains in the cerebrospinal fluid and ...
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ژورنال
عنوان ژورنال: Tenri Medical Bulletin
سال: 2018
ISSN: 1344-1817,2187-2244
DOI: 10.12936/tenrikiyo.21-008